Autologous Fat Grafting for Oncologic Patients: A Literature Review

Abstract Autologous fat grafting (AFG) serves as an effective method to address volume defects, contour irregularities, and asymmetry in both aesthetic reconstructive procedures. In recent years, there has been growing concern about the potential of cancer recurrence interference with surveillance oncologic patients receiving AFG. The adipose tissue contains adipose-derived stem cells (ASCs), a specific type mesenchymal cells, that facilitate secretion numerous growth factors which turn stimulate regeneration angiogenesis. As such, it theorized ASCs may also have cell proliferation when used patients. Multiple research studies demonstrated ability ACSs tumor animal models. However, clinical yielded contradictory findings. Although literature pertaining safety head neck, well sarcoma, remains limited, demonstrate no increased risk these patient populations Similarly, efficacy AFG established breast through studies. More recently, preclinical models shown improve joint contracture following irradiation. Ultimately, further is needed elucidate variety patients, explore its use regeneration, particularly setting radiotherapy. Level Evidence: 4